PGC-1α is a central regulator of cellular and mitochondrial metabolism in metabolically highly active nonneuronal cell types—brown fat cells, cardiomyocytes, and muscle cells [1]. PGC-1α dysfunction is linked to diseased states of these cell types such as diabetes [2], cardiomyopathy [3], and sarcopenia [4]. PGC-1α orchestrates a remodeling of cells to increase “clean energy” production [5]. Here, PPARGC1A is linked to diabetes mellitus.