Adalimumab (Humira®, Human Monoclonal Antibody in Rheumatoid Arthritis) is a human monoclonal TNF-α antibody used to threat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis, and Chron's disease in case of other drugs' failure. The gene discussed is TNF; the disease is rheumatoid arthritis.