To further understand the relationship between JFK-induced effects on A549 cell and changes in H3K4Me3 levels at tumor-related genes, we analyzed the modification changes at five survival-regulated genes (SUSD2, PTN, GLIS2, CCND2, and TM4SF4) and five apoptosis-regulated genes (BCL2A1, IL31RA, WISP2, TNFAIP6, and TMEM158). This evidence concerns the gene GLIS2 and neoplasm.