Previous study has suggested that SUSD2 interacts with galectin-1 (Gal-1), a 14 kDa secreted protein that is synthesized by carcinoma cells and promotes tumor immune evasion, angiogenesis, and metastasis [35]. CCND2 is a cyclin whose function is to regulate the subunit of CDK4 or CDK6 and whose activity is required for cell cycle G1/S transition [36]. This evidence concerns the gene CDK4 and carcinoma.