Here, Gene Ontology analysis indicated that JFK-induced A549 cell proliferation inhibition and apoptosis promotion could be due to the alteration of levels of H3K4Me3 modification on genes that belong to multiple tumor-related pathways including pathways in cancer, basal cell carcinoma, apoptosis, regulation of transcription (DNA-templated), and regulation of peptidase activity. This evidence concerns the gene FBXO42 and basal cell carcinoma.