MSH2 and hereditary nonpolyposis colon cancer: Hereditary Nonpolyposis Colon Cancer (HNPCC) is another syndrome with reported mutations in the mismatch repair gene (MMR) complexes that include several mutations as hMLH1 at 3p21.3, hMSH2 at 2p22–p21, hPMS1 at 2q31–q33, hPMS2 at 7p22, and hMSH6 at 2p16 [6].