Notably, while PDA KRASG12D expression does not activate AKT in a cell-autonomous manner (Figures 2 and S3), tumor cell AKT substrate phosphosites (e.g., AKTS1 [pT247] and GSK3α [pS21]) are exclusively regulated by stromal PSCs (Figures S4C–S4E). The gene discussed is AKT1; the disease is neoplasm.