Targeted temporal analysis revealed SHH-activated PSCs induce rapid phosphorylation of IGF1R (receptor for IGF-1), AXL/TYRO3 (receptor for GAS6), and downstream IRS-1 and AKT (pT308/pS473) in KRASG12D PDA cells (Figure 3D). The gene discussed is IRS1; the disease is Patent ductus arteriosus.