INS and type 2 diabetes mellitus: In a randomized, double-blind, placebo-controlled trial, insulin-mediated glucose disposal was measured in 12 obese patients with non-insulin dependent DM (NIDDM) on diet alone before and after four weeks of treatment with either placebo or fluoxetine and it was found that fluoxetine improves insulin-mediated glucose disposal in obese patients with NIDDM (6).