Intriguingly, there are striking differences between the phenotypes of the HFD-fed MNK1- and MNK2-KO mice; while HFD-fed MNK2-KO show reduced weight gain and greatly diminished adipose tissue inflammation, MNK1-KO mice show similar increases in fat mass and inflammatory markers to WT animals on the HFD, but are nonetheless protected to a similar extent against HFD-induced insulin resistance and glucose intolerance. The gene discussed is MKNK1; the disease is Insulin resistance.