Compared with controls, the CLM values for CYP2C9, 2D6, and 2E1 increased in HCC patients (P=7.96E-5, 2.91E-3, and 1.56E-21, respectively), while those values for CYP1A2, 2C8, and 2C19 were lower (P=9.61E-9, 1.19E-24, and 3.61E-4, respectively). Here, CYP1A2 is linked to hepatocellular carcinoma.