No data on the in vivo clearance for CYPs in HCC patients was identified in a literature search, and only data regarding the clearance for CYP2C19 (67±40 ml/min) and CYP3A4/5 (319.49±154.42 ml/min) in liver cirrhosis were queried. This evidence concerns the gene CYP3A4 and cirrhosis of liver.