As shown in Figure 1, the CLL values for CYP1A2, 2A6, 2B6, 2C8, 2C19, and 3A4/5 in HCC patients were dramatically lower than in controls (P=1.04E-13, 1.92E-7, 8.99E-4, 3.77E-27, 6.71E-10, and 3.10E-4, respectively), while the CLL value for CYP2E1 was higher (P=1.27E-3) and the CLL value for CYP2C9 and 2D6 showed no significant difference. This evidence concerns the gene CYP2E1 and hepatocellular carcinoma.