Consistent with marked suppression of tumor growth and the observed pharmacodynamic inhibition of the c-Met phosphorylation, immunohistochemical analysis of the tumor specimens revealed that HVS treatment suppressed both mitosis and new vessel formation, as evidenced by the significant reduction of the expression of their markers, Ki-67 and CD-31, respectively, compared to the vehicle-treated group (Figure 10E). The gene discussed is MKI67; the disease is neoplasm.