Hence, the difference in the estimated parameters, especially for the basic reproduction number (\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$ R_{0} = rT\left( 0 \right)/\delta $$\end{document}R0=rT0/δ), between WT HIV-1 and HIV-1Δvpu infection reflects the overall role of Vpu in humanized mouse model. The gene discussed is SGTA; the disease is infection.