The demonstration that SSTR5 is highly expressed in the majority of human corticotroph adenomas and is more resistant to glucocorticoid down-regulation, has led to the development of the novel somatostatin analogues, notably pasireotide that binds SSTR1, 2, 3 and, with maximal affinity, SSTR5 [65]. The gene discussed is SSTR5; the disease is ACTH-producing pituitary gland adenoma.