CYP17A1 and Cowden syndrome 1: Suppression of adrenal secretion, primarily by inhibition of 11-beta-hydroxylase (CYP11B1) and, to a lesser extent, 17-hydroxylase (CYP17A1) and 20,22 desmolase (CYP11A1) [31], proved useful for rapid reversal of hypercortisolism as has been achieved in patients with severe CS, e.g., uncontained psychosis, sepsis [32].