Recent research attempted to widen the use of octreotide, that binds SSTR2, 3 and 5, in endogenous hypercortisolism and assessed its effect in patients with primary pigmented nodular adrenocortical disease (PPNAD), a form of ACTH-independent hypercortisolism characterized by dense expression of most somatostatin receptors in adrenal nodules. This evidence concerns the gene POMC and primary pigmented nodular adrenocortical disease.