SOD1 and early-onset autosomal dominant Alzheimer disease: We compared our differentially regulated gene set to genes that were activated in microglia and/or astrocytes in the spinal cord of transgenic mice for mutant G93A SOD1, a model of amyotrophic lateral sclerosis (Chiu et al., 2013), or the cortex of mice transgenic for both the APPSwe and PS1dE9 genes, a commonly used Alzheimer’s Disease model (Orre et al., 2014) (Glia Open Access Database) (Holtman et al., 2015).