Recent studies in human cervical and pancreatic cancers have demonstrated that the direct interaction of PHB with C-Raf is required for the localization and phosphorylation of C-Raf at serine 338 at the plasma membrane and results in the RAS-mediated activation of Raf and the downstream activation of the ERK pathway [13, 14, 25]. Here, PHB1 is linked to pancreatic neoplasm.