Although fibrillar α-Syn could induce the synthesis of interleukin-1β (IL-1β) through interaction with Toll-like receptor 2 (TLR2) and activation of inflammasome in monocytes in vitro [6], the role of α-Syn-induced inflammasome activation in the onset of PD has not yet been fully established [7]. Here, IL1B is linked to Parkinson disease.