TREM1 and glioblastoma: Although soluble TREM-1 was elevated in the serum of 129/SvJ compared to control B6 mice at later timepoints (days 14 and 21), this was correlated with a slight decrease in B6 serum soluble TREM-1 levels at days 14 and 21 in response to anti-GBM treatment (Fig. 1c).