Paralleling the GBM subtype-specific effects of NFIB, we observed increased p-STAT3 in classical and mesenchymal GBM cells, no change in p-STAT3 expression in proneural GBM cells and a decrease in p-STAT3 in neural GBM cells (Figure 5A and 5B). This evidence concerns the gene STAT3 and glioblastoma.