The killing activity of TU17:MTD or TU17-2:MTD on tumor tissues was substantially inhibited when the anti-NRP-1 antibody was pre-injected into tumor-bearing mice in vivo (Figure 6B), and the extent to which TU17:MTD or TU17-2:MTD injection reduced tumor volume at day 1 was significantly decreased (Figure 6C). This evidence concerns the gene NRP1 and neoplasm.