The binding of Endothelin-1 (ET-1) to ET-1 receptor can stimulate growth of breast cancer cells by autocrine and paracrine signaling, and increased expression of ET-1, Endothelin A receptor (ETAR), and Endothelin B receptor (ETBR) in breast cancer patients lowers disease-free survival time and overall survival [50]. The gene discussed is EDN1; the disease is breast carcinoma.