BLM and skin neoplasm: To explore an immediate opportunity for prevention and diagnosis of DNA damage-related diseases including UV-driven skin cancers, we modified the conventional TaqMan assay at the annealing stage to differentiate the peaks of probe fluorescence bound to wt and mt templates (Blm cDNA) respectively (Figure 5A) (the probe sequence was designed upon the Y974Q975 region of BLM: FAM-GGTTACTACCAAGAATCT).