48]. Antidepressants and mood stabilizing agents specifically alter IL-1β, IL-6 and IFN-γ implicated widely in depressive disorders [49, 50. 51]. The elevation in proinflammatory cytokines in the brain is induced by various extracellular stimuli such as stress and may cause overload of reactive oxygen species and reactive nitrogen species, glutamate excitotoxicity and blood brain barrier disruption [8]. The gene discussed is IL1B; the disease is depressive disorder.