In addition to the protective role of lncRNA, we demonstrate in the present study that the newly identified lncRNA-ROR promotes cardiac hypertrophy by showing that the expression of lncRNA-ROR is dramatically increased in both hypertrophic heart and in vitro cultured cardiomyocytes subject to PE treatment, which are associated with increased expression of fetal genes ANP and BNP. This evidence concerns the gene NPPA and cardiac hypertrophy.