NPPB and cardiac hypertrophy: In addition to the protective role of lncRNA, we demonstrate in the present study that the newly identified lncRNA-ROR promotes cardiac hypertrophy by showing that the expression of lncRNA-ROR is dramatically increased in both hypertrophic heart and in vitro cultured cardiomyocytes subject to PE treatment, which are associated with increased expression of fetal genes ANP and BNP.