Here, DM2h immune reactivity does not appear to enhance ETI conditioned by other TNL genes (S9 Fig), suggesting a degree of specificity in DM2h co-action with DM2c and EDS1. Further analysis is required to establish whether DM2h and DM2c interact genetically or molecularly with each other, as found for a number of functional NLR and NOD-LRR receptor pairs [3, 5], or indeed with nuclear EDS1, in the different autoimmunity backgrounds. Here, TRIM67 is linked to Autoimmunity.