CD79A and systemic lupus erythematosus: The eQTL analysis also reported a significant association between the rs4917014 genotype and increased expression of genes involved in the type 1 interferon response (trans-effect).40 Given that increased expression of interferon-α response genes is a distinct expression pattern in SLE patients,44 and that the rs4917014 genotype confers susceptibility to SLE,28 the increased C pneumoniae IgA levels and higher risk of SLE in individuals with the risk allele might partially share a common pathophysiological pathway.