According to a United Kingdom Prospective Diabetes Study report, patients with DKD and macroalbuminuria progress to renal failure, although a substantial number of patients with diabetes without albuminuria and those with microalbuminuria also show renal dysfunction.8 MacIsaac et al9 also reported that 39% of diabetic patients with advanced (over stage 3) chronic kidney disease (CKD) had urine albumin levels in the normal range. The gene discussed is ALB; the disease is diabetes mellitus.