CYLD is a K63- and M1-specific DUB [51]; and vOTU is an ovarian tumor (OTU) domain-containing DUB from Crimean-Congo hemorrhagic fever virus (CCHFV) large (L) protein [52] that can cleave all kinds of Ub linkages except M1 linkage [53]. Here, CYLD is linked to ovarian neoplasm.