To determine the potential correlation between MDM2 del1518 status and cancer risk, we analyzed the distribution of this variant in large sample sets of incident cases of four major cancer forms (1,717 breast, 1,532 colon, 1,331 lung and 2,501 prostate cancer samples) drawn from the population-based Cohort of Norway (CONOR) [31] and compared the distribution to 3,749 matched controls without any cancer from the same cohort. Here, MDM2 is linked to prostate carcinoma.