KDR and neoplasm: When combined with anti-VEGFR-2 treatment, Ang-2 destabilized vessels and compromised the survival benefit of VEGFR-2 inhibition by increasing vascular permeability, suggesting that VEGFR-2 inhibition normalized tumor vasculature, whereas ectopic expression of Ang-2 diminished the beneficial effects of VEGFR-2 blockade by inhibiting vessel normalization.