In vivo, Masson staining (Figure 8C) and quantification of collagen (Figure 8D) evaluation showed hPP10-GCLC treatment significantly decreased collagens content in rat model, including CCL4-induced liver fibrosis (Figure 8C and 8D) and pig serum-induced liver fibrosis model (Figure 8E and 8F). This evidence concerns the gene CCL4 and Hepatic fibrosis.