Many studies, including the Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP) trial, Scandinavian Starch for Severe Sepsis/Septic Shock (6S) trial, and Crystalloid vs. Hydroxy-Ethyl Starch Trials (CHEST) were conducted to compare the efficacy of each in septic patients. This evidence concerns the gene INS and Sepsis.