Additional pro-inflammatory markers, including interleukin (IL)-6, C-reactive protein (CRP), matrix metalloproteinases (MMPs), cytosolic phospholipase A2 (cPLA2), cyclooxygenase-2 (COX-2) and TNF-α are consistently elevated in neurodegenerative diseases, which are largely associated with chronically elevated levels of ROS [5, 38]. This evidence concerns the gene CRP and neurodegenerative disease.