2003). The precise role of MST‐1 in human HF remains to be determined, but apoptosis plays a role in cardiac remodeling (Cesselli et al. 2001) and is relevant to the pathogenesis of human HF (van Empel et al. 2005). Importantly, there is evidence that oxidative stress can induce apoptosis which provides a basis to target oxidative stress to reduce apoptosis‐induced cardiac remodeling (Kumar et al. 2002). This evidence concerns the gene MST1 and hydrops fetalis.