CTLA4 and Renal insufficiency: We examined the relations between CTLA-4 SNPs (rs733618, rs4553808, rs5742909, rs231775 and rs3087243) and eGFR (eGFR < 90 mL/min/1.73 m2 was identified as renal failure and was staged according to the KDIGO guidelines) over a period of 60 months in recipients of kidney transplants.