CASP3 and glioblastoma: miR-21 has been identified as over-expressed in glioblastoma and to play a role in apoptosis, since suppression of miR-21 triggered activation of caspases 3 and 7 and increased programmed cell death in glioblastoma cells [32] thus demonstrating that miR-21 over-expression contributes to glioblastoma oncogenesis by silencing apoptosis-related genes.