HOXC6 and neoplasm: In univariate analysis, OS was significantly associated with preoperative CEA (P < 0.001), primary tumor differentiation (P = 0.015), primary pT stage (P < 0.001), primary pN stage (P < 0.001), synchronous distant metastases (P < 0.001), HOXC6 expression (P < 0.001), postoperative adjuvant chemotherapy (P < 0.001) and treatment for metastases (P < 0.001) (Table 2).