S100A8 and colorectal carcinoma: For example, the levels of S100A8 and S100A9 were significantly increased in the TIF at weeks 18 and 22, which corroborated the findings of Kim et al.: the levels of these two proteins were higher in the plasma of CRC and colorectal adenoma patients, and the areas under ROC curves for the two proteins were superior to that of CEA [26].