Interestingly, cancer stromal staining of PRSS8 was well correlated with stromal lymphocyte infiltration, in which, 37% (77/207) of cancer stroma showed higher PRSS8 expression if the stroma presented visible lymphocyte infiltration, whereas, only 21% (33/155) of the stroma showed higher expression of PRSS8 if the stroma did not present visible lymphocyte infiltration, the difference was statistically significant (p=0.001, Table 1). Here, PRSS8 is linked to cancer.