Previous studies have reported that the inactivation of tumor suppressor genes was one of the major causes of esophageal carcinogenesis, and hypermethylation-induced silence of tumor suppressors, such as P16 [31, 32], E-cadherin [27] and selenium-binding protein 1 [33], etc, are frequently observed in esophageal cancers. The gene discussed is SELENBP1; the disease is neoplasm.