TGFB1 and cancer: (Fig. 3 and Additional file 1: Figure S4) A recent article by Babu et al. [27] suggests that the TGF-β1-mediated suppression of CD248 is present in normal murine embryonic fibroblasts but not murine lymphoma cell lines or in cancer-associated fibroblasts suggesting perhaps that the local cellular environment influences CD248 expression.