Recently, it was shown that S1P2 knockout mice uniformly exhibit a progressive loss of inner ear function, resulting in profound deafness and vestibular dysfunction, demonstrating that S1P2 activity is necessary for cochlear viability19, 20, 21 that was a ligand-dependent process since loss of S1P transporter gene Spns2 phenocopies S1P2 loss22. Here, S1PR2 is linked to deafness.