Previous work has already suggested inter-relationships for TNF-P2X7 receptor signaling in other cellular contexts, such as P2X7 receptor expression modulation in immune cells in Behçet's disease [19] or the P2X7 receptor-dependent regulation of TNF release in microglial cells [18] (Further work will elucidate the context of P2X7 receptor–TNF interactions in the biology of P. falciparum. The gene discussed is TNF; the disease is Behcet disease.