INS and Insulin resistance: Inflammation pathways were coordinately up-regulated with insulin resistance and adipokines, e.g., the chemokine signaling pathway correlated with insulin sensitivity (Matsuda index) (r = −0.807), fs-insulin (r = 0.858), fs-adiponectin (r = −0.598) and leptin (r = 0.428) (p < 0.001 for all).