PANK2 and Parkinson disease: Examples of CNS iron misregulation associated with diseases include Friedreich’s ataxia, associated with neuronal and myocardial mitochondrial iron accumulation [1, 2], Hallervorden-Spatz syndrome (defect on pantothenate kinase 2 - PANK2), characterized by marked iron overload in the globus pallidus [3], aceruloplasminemia, generated by an iron overload in basal ganglia [4], and Parkinson’s disease, where iron accumulation is found in the substantia nigra [5].