TNF and infection: In line with this observation, NOTCH1-responsive PI3K-mTOR-NF-κB axis was found essential for generation of M. bovis BCG-induced inflammatory cytokines like IL-6, TNF-α and IL-12 despite for the fact that no change in the infection-induced DC maturation was observed when PI3K-mTOR-NF-κB pathway was inhibited (Fig. 7g).