Familial ALS/FTD mutations in CCNF were present in the overall cohorts from these diverse geographic populations at frequencies ranging from 0.6 to 3.3%, which is comparable to the frequency of mutations in TARDBP (which encodes TDP-43) and FUS that have been reported in familial ALS cohorts13. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.