We also found that allele-specific knockdown of mutant huntingtin expression in HD GMSLNs using antisense oligonucleotide (Additional file 1: Figure S3C) decreased amplitude of abnormal SOC-mediated calcium entry from 4.62 ± 0.61 pA/pF in cells transfected with control LNA(S) to 2.29 ± 0.38 pA/pF in cells transfected with LNA(T) targeting mHTT (Fig. 3d, f). Here, HTT is linked to Huntington disease.