GFAP and amyotrophic lateral sclerosis: A number of studies have shown that glial cells may play a crucial role in the pathogenesis of mammalian ALS, and it is worth noting that we found a significant increase in GFAP in the spinal cords of mSod1 and wtSod1 adult zebrafish, which in line with the gradual increase in astrogliosis that parallels disease progression in mice expressing mSOD1 or wtSOD125.