PFKFB3 and cancer: In cancer cells, an increase in glycolysis, resulted from the elevated PFKFB3 expression and/or iPFK2 activity, can at least 1) provide ATP to support physiological needs of cancer cells; 2) decrease pH value of microenvironment which contributes to increased apoptosis of normal cells; and 3) supply biosynthetic precursors such as fructose-6-phosphate and glyceraldehyde-3-phosphate for de novo nucleic acid synthesis.