Here, we found that whilst GLP-1(9–36) had no effect on echocardiographic systolic function post-MI, as indexed by LVESV, ejection fraction and fractional shortening, GLP-1(9–36) significantly attenuated diastolic dysfunction, as indicated by increased mitral valve E/A ratio (improved LV filling) and reduced E wave deceleration rate (improved LV compliance), although LV dilatation associated with MI remained unchanged. The gene discussed is GCG; the disease is myocardial infarction.