A meta-analysis of association studies published on the subject in 2012, reported lack of association of 3 SNPs (i.e. IL1B -511 C>T, IL1B+3954 C>T and IL1RN 86bp VNTR) residing in IL-1 gene cluster with CAD.[10] However, since risk of a genetically heritable disease is known to differ in different ethnic populations, we hypothesized that investigating the association of IL-1 gene cluster SNPs with CAD within several specific ancestral groups employing an updated meta-analysis of association studies might end up generating valuable information on the subject. This evidence concerns the gene IL1RN and coronary artery disorder.