Over the last decade, these aforementioned IL1B SNPs have been extensively investigated with respect to CAD/MI, yielding negative results.[25–27, 31, 32, 34–36, 38] Lack of association for -3954 C>T polymorphism with CAD has even been attested before, vide a published meta-analysis[10]. This evidence concerns the gene IL1B and coronary artery disorder.