IL1RN and coronary artery disorder: Our pooled result also concurs with the CARDIoGRAMplusC4D GWAS data, which incidentally is the most comprehensive meta-analysis of published GWAS studies on the subject.[51] Severe ancestral diversity was however seen in terms of association with CAD, for at least four SNPs residing in the IL-1 gene cluster (i.e. for IL1A +4845 G>T, IL1B -511 C>T, IL1RN +8006 T>C and IL1RN 86bp VNTR) which duly qualifies to be a highlight of the present meta-analysis.