This group also included proteins associated with metabolism and apoptosis, included proteins that were reported in other cancers, including liver and brain tumors, but not CLL, such as VDAC1, VDAC2, AIF and other mitochondrial proteins associated with metabolism and apoptosis regulation (Fig 1C and Table 1, group B). This evidence concerns the gene VDAC1 and B-cell chronic lymphocytic leukemia.