Owing to limited access to CLL samples and their low stability, we instead used MEC-1 cells derived from B-chronic lymphocytic leukemia in prolymphocytoid transformation [64] to analyze the effects of siRNA-mediated down-regulated expression of DDX46 and AK3 on cell viability (Fig 2D). This evidence concerns the gene AK3 and B-cell chronic lymphocytic leukemia.