AIFM1 and B-cell chronic lymphocytic leukemia: Unexpectedly, the mitochondrial pro-apoptotic proteins AIF [67] and SMAC/Diablo [68] were also over-expressed (1.9- and 4-fold on average, respectively) in PBMCs derived from CLL patients, as compared with healthy donors (Fig 3Ad and 3Ae, respectively and 3B)).