When focusing on the apoptotic modulating proteins, the binary logistic regression model [33] employed here demonstrated that SMAC/Diablo, AIF, MAVS, VDAC1 or Bcl-2 are with high potential as diagnostic markers of >90% accuracy when using Bivariance analysis, and AUC values of 0.97 to 1.0 in the ROC curve analysis for CLL diagnosis (Fig 6). This evidence concerns the gene VDAC1 and B-cell chronic lymphocytic leukemia.