VDAC1 was found to be over-expressed in several types of cancers, such as lung, cervical, thyroide and ovarey cancer [46,91,92], yet this report is the first to demonstrate VDAC1 over-expression in CLL (Figs 3 and 4 and Table 1). This evidence concerns the gene VDAC1 and B-cell chronic lymphocytic leukemia.