Interestingly, ectonucleotide pyrop-hosphatase/phosphodiesterase 4 (ENPP4), involved in hydrolyze phosphodiester bonds and acting as a pro-coagulant and highly expressed in the metastatic osteosarcoma cells [87], was highly reduced (51.8-fold) in CLL group B (Table 2, Fig 7B). This evidence concerns the gene ENPP4 and osteosarcoma.