Finally, to further test the prognostic value of AP3B, ADH5, DDX46 and AK3 proteins in CLL, we used Kaplan-Meier survival analysis on public available gene expression data a set of CLL patients in which the percent of patients surviving with high mRNA levels was compared to the survival of patients with low mRNA levels. This evidence concerns the gene DDX46 and B-cell chronic lymphocytic leukemia.