Our results confirm the over-expression of the anti-apoptotic protein Bcl-2, leading to clonal B cell expansion [5,7], and the decreased expression of the pro-apoptotic protein Bax in CLL [10,11,66], due to its abnormally increased degradation by the ubiquitin-proteasomal pathway [10]. This evidence concerns the gene BAX and B-cell chronic lymphocytic leukemia.