To explore whether p-Src promotes NPC cells motility through EMT process, we evaluated the expression of c-Src, p-Src and EMT markers by western blotting in stable cell lines, including S18-koSrc, 5-8F-koSrc and S26-Src, or their parental cell lines after PP2 treatment. The gene discussed is SRC; the disease is nasopharyngeal carcinoma.